Jan J. Sciciński: search on Z-Library

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1

Follow the ATP: Tumor Energy Production: A Perspective

Oronsky, Bryan, Oronsky, Neil, Fanger, Gary, Parker, Christopher, Caroen, Scott, Lybeck, Michelle, Scicinski, Jan

Journal:

Anti-Cancer Agents in Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 786 KB

english, 2014

2

Six Degrees of Separation: The Oxygen Effect in the Development of Radiosensitizers

Oronsky, Bryan T., Knox, Susan J., Scicinski, Jan

Journal:

Translational Oncology

Year:

2011

Language:

english

File:

PDF, 290 KB

english, 2011

3

Is Nitric Oxide (NO) the Last Word in Radiosensitization? A Review

Oronsky, Bryan T., Knox, Susan J., Scicinski, Jan J.

Journal:

Translational Oncology

Year:

2012

Language:

english

File:

PDF, 188 KB

english, 2012

4

Rapid one-pot preparation of 2-substituted benzimidazoles from 2-nitroanilines using microwave conditions

David S. VanVliet, Paul Gillespie, Jan J. Scicinski

Journal:

Tetrahedron Letters

Year:

2005

Language:

english

File:

PDF, 97 KB

english, 2005

5

Going viral: a review of replication-selective oncolytic adenoviruses

Larson, Christopher, Oronsky, Bryan, Scicinski, Jan, Fanger, Gary R., Stirn, Meaghan, Oronsky, Arnold, Reid, Tony R.

Journal:

Year:

2015

Language:

english

File:

PDF, 974 KB

english, 2015

6

The development of a ‘safety-catch’ arylgermane for biaryl synthesis by palladium-catalysed germyl-stille cross-coupling

Alan C. Spivey, Christopher J. G. Gripton, Joseph P. Hannah, Chih-Chung Tseng, Paul de Fraine, Nigel J. Parr, Jan J. Scicinski

Journal:

Applied Organometallic Chemistry

Year:

2007

Language:

english

File:

PDF, 360 KB

english, 2007

7

Rapid One-Pot Preparation of 2-Substituted Benzimidazoles from 2-Nitroanilines Using Microwave Conditions.

David S. VanVliet, Paul Gillespie, Jan J. Scicinski

Journal:

Year:

2006

File:

PDF, 18 KB

2006

8

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders || Cancer and Beyond: Discovery and Development of NO-Releasing Therapeutics

Year:

2019

Language:

english

File:

PDF, 2.65 MB

english, 2019

9

RRx-001: a systemically non-toxic M2-to-M1 macrophage stimulating and prosensitizing agent in Phase II clinical trials

Oronsky, Bryan, Paulmurugan, Ramasamy, Foygel, Kira, Scicinski, Jan, Knox, Susan J., Peehl, Donna, Zhao, Hongjuan, Ning, Shoucheng, Cabrales, Pedro, Summers, Thomas A., Reid, Tony R., Fitch, William L

Journal:

Expert Opinion on Investigational Drugs

Year:

2017

Language:

english

File:

PDF, 1.15 MB

english, 2017

10

Chemical libraries in drug discovery

Jan J. Scicinski

Journal:

Trends in Biotechnology

Year:

1995

Language:

english

File:

PDF, 278 KB

english, 1995

11

Single Bead Characterization Using Analytical Constructs: Application to Quality Control of Libraries

Lorthioir, Olivier, Carr, Robin A. E., Congreve, Miles S., Geysen, Mario H., Kay, Corinne, Marshall, Peter, McKeown, Stephen C., Parr, Nigel J., Scicinski, Jan J., Watson, Stephen P.

Journal:

Analytical Chemistry

Year:

2001

Language:

english

File:

PDF, 108 KB

english, 2001

12

Analysis of Solid-Phase Reactions: Product Identification and Quantification by Use of UV-Chromophore-Containing Dual-Linker Analytical Constructs

Geoff M. Williams, Robin A. E. Carr, Miles S. Congreve, Corinne Kay, Stephen C. McKeown, Peter J. Murray, Jan J. Scicinski, Stephen P. Watson

Journal:

Angewandte Chemie International Edition

Year:

2000

Language:

english

File:

PDF, 191 KB

english, 2000

13

ChemInform Abstract: Analytical Construct Resins for Analysis of Solid-Phase Chemistry

Miles S. Congreve, Steven V. Ley, Jan J. Scicinski

Journal:

Year:

2002

File:

PDF, 25 KB

2002

14

ChemInform Abstract: Identification of Potent and Selective Oxytocin Antagonists. Part 1. Indole and Benzofuran Derivatives.

Paul G. Wyatt, Michael J. Allen, Josie Chilcott, Alison Foster, David G. Livermore, Jackie E. Mordaunt, Jan Scicinski, Patrick M. Woollard

Journal:

Year:

2002

File:

PDF, 31 KB

2002

15

The squalestatins: Synthesis of c-4 carboxamide derivatives

Chuen Chan, Jan J Scicinski, Anton Rp Srikantha, Nigel S Watson

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 291 KB

english, 1996

16

Safety and activity of RRx-001 in patients with advanced cancer: a first-in-human, open-label, dose-escalation phase 1 study

Reid, Tony, Oronsky, Bryan, Scicinski, Jan, Scribner, Curt L, Knox, Susan J, Ning, Shoucheng, Peehl, Donna M, Korn, Ron, Stirn, Meaghan, Carter, Corey A, Oronsky, Arnold, Taylor, Michael J, Fitch, Wil

Journal:

The Lancet Oncology

Year:

2015

Language:

english

File:

PDF, 553 KB

english, 2015

17

Versatile solid-phase synthesis of secondary amines from alcohols. Development of an N-Boc-(o-nitrobenzene)sulfonamide linker

Miles S. Congreve, Corinne Kay, Jan J. Scicinski, Steven V. Ley, Geoffrey Williams, Peter J. Murray, Stephen C. McKeown, Stephen P. Watson

Journal:

Tetrahedron Letters

Year:

2003

Language:

english

File:

PDF, 256 KB

english, 2003

18

Oral coadministration of β-glucuronidase to increase exposure of extensively glucuronidated drugs that undergo enterohepatic recirculation

Gary Eichenbaum, C.-P. Hsu, Vangala Subrahmanyam, Jing Chen, Jan Scicinski, Robert A. Galemmo Jr., Robert W. Tuman, Dana L. Johnson

Journal:

Journal of Pharmaceutical Sciences

Year:

2012

Language:

english

File:

PDF, 349 KB

english, 2012

19

Turning on the Radio: Epigenetic Inhibitors as Potential Radiopriming Agents

Oronsky, Bryan, Scicinski, Jan, Kim, Michelle, Cabrales, Pedro, Salacz, Michael, Carter, Corey, Oronsky, Neil, Lybeck, Harry, Lybeck, Michelle, Larson, Christopher, Reid, Tony, Oronsky, Arnold

Journal:

Year:

2016

Language:

english

File:

PDF, 1.15 MB

english, 2016

20

The War on Cancer: A Military Perspective

Oronsky, Bryan, Carter, Corey A., Mackie, Vernon, Scicinski, Jan, Oronsky, Arnold, Oronsky, Neil, Caroen, Scott, Parker, Christopher, Lybeck, Michelle, Reid, Tony

Journal:

Frontiers in Oncology

Year:

2015

Language:

english

File:

PDF, 692 KB

english, 2015

21

Conversion of Platinum-Etoposide-Resistant to Sensitive SCLC after Treatment with the Epi-Immunotherapeutic RRx-001: A Case Report

Brzezniak, Christina, Oronsky, Bryan, Scicinski, Jan, Caroen, Scott, Cabrales, Pedro, Dean Abrouk, Nacer, Kim, Michelle M., Brown, James F., Reid, Tony R., Larson, Christopher, Oronsky, Arnold, Day, R

Journal:

Oncology Research and Treatment

Year:

2016

Language:

english

File:

PDF, 521 KB

english, 2016

22

Clean synthesis of α-bromo ketones and their utilisation in the synthesis of 2-alkoxy-2,3-dihydro-2-aryl-1,4-benzodioxanes, 2-amino-4-aryl-1,3-thiazoles and piperidino-2-amino-1,3-thiazoles using polymer-supported reagents

Habermann, Jörg, Ley, Steven V., Scicinski, Jan J., Scott, James S., Smits, René, Thomas, Andrew W.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1999

Language:

english

File:

PDF, 110 KB

english, 1999

23

RRx-001, A novel dinitroazetidine radiosensitizer

Oronsky, Bryan, Scicinski, Jan, Ning, Shoucheng, Peehl, Donna, Oronsky, Arnold, Cabrales, Pedro, Bednarski, Mark, Knox, Susan

Journal:

Investigational New Drugs

Year:

2016

Language:

english

File:

PDF, 1.13 MB

english, 2016

24

The immunomodulatory anticancer agent, RRx-001, induces an interferon response through epigenetic induction of viral mimicry

Zhao, Hongjuan, Ning, Shoucheng, Nolley, Rosalie, Scicinski, Jan, Oronsky, Bryan, Knox, Susan J., Peehl, Donna M.

Journal:

Clinical Epigenetics

Year:

2017

Language:

english

File:

PDF, 2.61 MB

english, 2017

25

P2.06-031 QUADRUPLE THREAT: A Pilot Phase 2 Study of RRx-001 in Advanced Lung Cancer Prior to Re-Administration of Platinum Doublets

Brzezniak, Christina, Quinn, Mary, Zeman, Karen, Oronsky, Bryan, Scicinski, Jan, Caroen, Scott, Abrouk, Nacer, Degesys, Aiste, Schmitz, Bruno, Peterson, Paul, Roswarski, Joe, Trepel, Jane, Lee, Min-Ju

Journal:

Journal of Thoracic Oncology

Year:

2017

Language:

english

File:

PDF, 203 KB

english, 2017

26

Rapid reaction scanning of solid phase chemistry using resins incocorporating analytical constructs

Peter John Murray, Corinne Kay, Jan J. Sciciński, Stephen C. McKeown, Stephen P. Watson, Robin A.E. Carr

Journal:

Tetrahedron Letters

Year:

1999

Language:

english

File:

PDF, 247 KB

english, 1999

27

The Implications of Hyponitroxia in Cancer

Oronsky, Bryan, Fanger, Gary R., Oronsky, Neil, Knox, Susan, Scicinski, Jan

Journal:

Translational Oncology

Year:

2014

Language:

english

File:

PDF, 590 KB

english, 2014

28

Approaches to carbocyclic analogues of the potent neuraminidase inhibitor 4-guanidino-Neu5Ac2en. X-Ray molecular structure of N-[(1S,2S,6R)-2-azido-6-benzyloxymethyl-4-formylcyclohex-3-enyl]acetamide

Chandler, Malcolm, Conroy, Richard, Cooper, Anthony W. J., Lamont, R. Brian, Scicinski, Jan J., Smart, James E., Storer, Richard, Weir, Niall G., Wilson, Richard D., Wyatt, Paul G.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1995

Language:

english

File:

PDF, 1.19 MB

english, 1995

29

NO to cancer: The complex and multifaceted role of nitric oxide and the epigenetic nitric oxide donor, RRx-001

Scicinski, Jan, Oronsky, Bryan, Ning, Shoucheng, Knox, Susan, Peehl, Donna, Kim, Michelle M., Langecker, Peter, Fanger, Gary

Journal:

Year:

2015

Language:

english

File:

PDF, 3.48 MB

english, 2015

30

Partial response to carboplatin in an RRx-001 pretreated patient with EGFR-inhibitor-resistance and T790M-negative NSCLC

Carter, Corey A., Oronsky, Bryan, Caroen, Scott, Scicinski, Jan, Cabrales, Pedro, Degesys, Aiste, Brzezniak, Christina

Journal:

Respiratory Medicine Case Reports

Year:

2016

Language:

english

File:

PDF, 952 KB

english, 2016

31

RRx-001 in Refractory Small-Cell Lung Carcinoma: A Case Report of a Partial Response after a Third Reintroduction of Platinum Doublets

Carter, Corey A., Oronsky, Bryan T., Caroen, Scott Z., Scicinski, Jan J., Degesys, Aiste, Kim, Michelle M., Oronsky, Arnold L., Lybeck, Harry, Cabrales, Pedro, Oronsky, Neil, Reid, Tony, Roswarski, Jo

Journal:

Case Reports in Oncology

Year:

2016

Language:

english

File:

PDF, 810 KB

english, 2016

32

Episensitization: Defying Timeâ€™s Arrow

Oronsky, Bryan T., Oronsky, Arnold L., Lybeck, Michelle, Oronsky, Neil C., Scicinski, Jan J., Carter, Corey, Day, Regina M., Rodriguez Orengo, Jose F., Rodriguez-Torres, Maribel, Fanger, Gary F., Reid

Journal:

Frontiers in Oncology

Year:

2015

Language:

english

File:

PDF, 6.73 MB

english, 2015

33

Partial Response to Platinum Doublets in Refractory EGFR-Positive Non-Small Cell Lung Cancer Patients after RRx-001: Evidence of Episensitization

Carter, Corey A., Oronsky, Bryan T., Caroen, Scott Z., Scicinski, Jan J., Cabrales, Pedro, Reid, Tony, Degesys, Aiste, Jenkins, John, Brzezniak, Christina

Journal:

Case Reports in Oncology

Year:

2016

Language:

english

File:

PDF, 908 KB

english, 2016

34

Nitric Oxide as a Chemosensitizing Agent || RRx-001 Reset: Chemoresensitization via NO-Mediated M1 Macrophage Repolarization

Year:

2017

Language:

english

File:

PDF, 2.51 MB

english, 2017

35

Rewriting the Epigenetic Code for Tumor Resensitization: A Review

Oronsky, Bryan, Oronsky, Neil, Scicinski, Jan, Fanger, Gary, Lybeck, Michelle, Reid, Tony

Journal:

Translational Oncology

Year:

2014

Language:

english

File:

PDF, 355 KB

english, 2014

36

Solid-Phase Development of a 1-Hydroxybenzotriazole Linker for Heterocycle Synthesis Using Analytical Constructs

Scicinski, Jan J., Congreve, Miles S., Jamieson, Craig, Ley, Steven V., Newman, Emma S., Vinader, Victoria M., Carr, Robin A. E.

Journal:

Journal of Combinatorial Chemistry

Year:

2001

Language:

english

File:

PDF, 127 KB

english, 2001

37

Flushing Out Carcinoid Syndrome: Beneficial Effect of the Anticancer Epigenetic Agent RRx-001 in a Patient with a Treatment-Refractory Neuroendocrine Tumor

Carter, Corey A., Degesys, Aiste, Oronsky, Bryan, Scicinski, Jan, Caroen, Scott Z., Oronsky, Arnold L., Reid, Tony, Cabrales, Pedro, Roswarski, Joe

Journal:

Case Reports in Oncology

Year:

2015

Language:

english

File:

PDF, 863 KB

english, 2015

38

Development of methods for the bioanalysis of RRx-001 and metabolites

Scicinski, Jan, Oronsky, Bryan, Cooper, Vance, Taylor, Michael, Alexander, Mike, Hadar, Rebecca, Cosford, Rebecca, Fleischmann, Thomas, Fitch, William L

Journal:

Year:

2014

Language:

english

File:

PDF, 879 KB

english, 2014

39

Microwave-Assisted Saccharide Coupling with n-Pentenyl Glycosyl Donors.

Felix Mathew, K. N. Jayaprakash, Bert Fraser-Reid, Jessy Mathew, Jan Scicinski

Journal:

Year:

2004

File:

PDF, 101 KB

2004

40

The Scarlet Letter of Alkylation: A Mini Review of Selective Alkylating Agents

Oronsky, Bryan T., Reid, Tony, Knox, Susan J., Scicinski, Jan J.

Journal:

Translational Oncology

Year:

2012

Language:

english

File:

PDF, 131 KB

english, 2012

41

From METS to malaria: RRx-001, a multi-faceted anticancer agent with activity in cerebral malaria

Yalcin, Ozlem, Oronsky, Bryan, Carvalho, Leonardo, Kuypers, Frans, Scicinski, Jan, Cabrales, Pedro

Journal:

Malaria Journal

Year:

2015

Language:

english

File:

PDF, 3.51 MB

english, 2015

42

Dihydropyrancarboxamides Related to Zanamivir: A New Series of Inhibitors of Influenza Virus Sialidases. 1. Discovery, Synthesis, Biological Activity, and Structure−Activity Relationships of 4-Guanidino- and 4-Amino-4H-pyran-6-carboxamides

Smith, Paul W., Sollis, Steven L., Howes, Peter D., Cherry, Peter C., Starkey, Ian D., Cobley, Kevin N., Weston, Helen, Scicinski, Jan, Merritt, Andrew, Whittington, Andrew

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 203 KB

english, 1998

43

Novel nitric oxide generating compound glycidyl nitrate enhances the therapeutic efficacy of chemotherapy and radiotherapy

Ning, Shoucheng, Bednarski, Mark, Oronsky, Bryan, Scicinski, Jan, Knox, Susan J.

Journal:

Biochemical and Biophysical Research Communications

Year:

2014

Language:

english

File:

PDF, 429 KB

english, 2014

44

RRx-001, an epigenetic-based radio- and chemosensitizer, has vascular normalizing effects on SCCVII and U87 tumors

Oronsky, Bryan, Scicinski, Jan, Cabrales, Pedro, Minchinton, Andrew

Journal:

Clinical Epigenetics

Year:

2016

Language:

english

File:

PDF, 2.97 MB

english, 2016

45

Analytical Construct Resins for Analysis of Solid-Phase Chemistry

Miles S. Congreve, Steven V. Ley, Jan J. Scicinski

Journal:

Chemistry - A European Journal

Year:

2002

Language:

english

File:

PDF, 250 KB

english, 2002

46

Novel inhibitors of influenza sialidases related to GG167 structure-activity, crystallographic and Molecular dynamics studies with 4H-pyran-2-carboxylic acid 6-carboxamides

Paul W. Smith, Steven L. Sollis, Peter D. Howes, Peter C. Cherry, Kevin N. Cobley, Helen Taylor, Andrew R. Whittington, Jan Scicinski, Richard C. Bethell, Neil Taylor, Tadeusz Skarzynski, Anne Cleasby

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 289 KB

english, 1996

47

Meeting Announcements

Ning, Shoucheng, Bednarski, Mark, Oronsky, Bryan, Scicinski, Jan, Knox, Susan J.

Journal:

Journal of Renal Nutrition

Year:

2001

Language:

english

File:

PDF, 26 KB

english, 2001

48

The Squalestatins: Decarboxy and 4-Deoxy Analogues as Potent Squalene Synthase Inhibitors 1

Chan, Chuen, Andreotti, Daniele, Cox, Brian, Dymock, Brian W., Hutson, Julie L., Keeling, Suzanne E., McCarthy, Alun D., Procopiou, Panayiotis A., Ross, Barry C., Sareen, Meenu, Scicinski, Jan J., Sha

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 548 KB

english, 1996

49

Application of ReactArray Robotics and Design of Experiments Techniques in Optimisation of Supported Reagent Chemistry

Jamieson, Craig, Congreve, Miles S., Emiabata-Smith, David F., Ley, Steven V., Scicinski, Jan J.

Journal:

Organic Process Research & Development

Year:

2002

Language:

english

File:

PDF, 105 KB

english, 2002

50

Concurrent whole brain radiotherapy and RRx-001 for melanoma brain metastases

Kim, Michelle M., Parmar, Hemant, Cao, Yue, Knox, Susan J., Oronsky, Bryan, Scicinski, Jan, Lawrence, Theodore S., Lao, Christopher D.

Journal:

Year:

2016

Language:

english

File:

PDF, 189 KB

english, 2016

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